Discussions
Agrochemical Developmental and Reproductive Toxicology (DART) Evaluations
Developmental and reproductive toxicology studies evaluate the reproductive safety of pesticides after repeated or chronic exposure. DART has been a growing field in recent years and is under constant regulation and public scrutiny. Several agrochemicals have been shown to affect the sexual function, fertility and development of animals. As a result, regulatory agencies in many countries require evidence of their impacts on animal development as part of registration. As scientific knowledge and technology advance, novel data derived from research are needed to minimize their use in animals. BOC Sciences is ready to provide a suit of services to simplify and optimize DART to ensure your agrochemical's regulatory success.
A Suite of DART Studies for Your Agrochemical
OECD 414: Prenatal developmental toxicity study
OECD 421: Reproduction/developmental toxicity screening test
OECD 422: Combined repeated dose toxicity study with the reproduction/developmental toxicity screening test
OECD 416: Two-generation reproduction toxicity
OECD 443: Extended one-generation reproductive toxicity study (EOGRTS)
DART Endpoints Assay
Our expertise in histopathology, animal behavior and analysis allows us to analyze all a diverse of DART endpoints:
Histopathological capabilities
Fetal pathology including Wilson's sectioning and microdissection techniques, staining for bone and cartilage
Computer-assisted sperm assessment (CASA)
Specialist neuropathology and morphometric measurements of the brain
Specialist pathology of male and female reproductive organs