Discussions

6-azauridine is a uridine analogue with a histidine-like N-3 pKa. It is used as an antineoplastic antimetabolite as it interferes with pyrimidine biosynthesis, thereby preventing the formation of cellular nucleic acids. The antiviral effect of 6-azauridine has previously been documented for several virus types, including coronaviruses, flaviviruses and West Nile virus. This compound may thus act as a broad antiviral agent. 6-azauridine for SARS-CoV-2 has already been used in patients in the treatment of other diseases. It should be further considered for use, either alone or in combination, for the treatment of 2019-nCoA infection. Therefore, its potential usefulness in the treatment of 2019-nCoA infections should be further evaluated.