Discussions

The quantification of ribosomal proteins in biological samples has been routinely used for the diagnosis of diseases and monitoring the treatment. However, large-scale protein quantification in complex samples is still a challenging task, while ribosomal proteomics attracts more attention. In addition to their canonical ribosomal functions, multiple ribosomal proteins have extra-ribosomal functions resulting in cell cycle arrest and apoptosis. Defects in ribosome biogenesis, translation, and the functions of individual ribosomal proteins, including mutations in ribosomal proteins, have been linked to a diverse range of human congenital disorders termed ribosomopathies.