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A fusion protein made of two diabodies joined by an Fc region is known as recombinant Anti-Ad fiber knob x Anti-ITGAV Diabody-Fc. Two short linker scFvs from anti-Ad fiber knob and anti-ITGAV antibodies make up a diabody. An inter-chain pairing is formed by the VH and VL domains. Diverse diabodies are fused to the Fc segment, resulting in 2+2 antigen-binding valency and Fc-mediated effects or just extending the half-life. Adenoviral vectors can be retargeted by this BsAb to tumor cells. It can be applied in cancer gene therapy to deliver a therapeutic gene to tumor cells with the goal of efficient and targeted cell death.