Discussions

Overview of Single Cell Omics for Dendritic Cells

Specialized antigen-presenting cells known as DCs serve as important mediators of immunity and tolerance by starting T cell-mediated immune responses. DCs come in a variety of subtypes and are diverse in nature. Numerous studies have demonstrated the presence of plasmacytoid DCs (pDCs) and CD11c+ conventional DCs (cDCs), which are composed of either CD141+ or CD1c+ cells, in human blood.

The number of DC subtypes, their relationships to one another, and how they differ from other mononuclear phagocytes are all unknown. Recent advances in single-cell omics technologies, particularly scRNA-seq, provide a direct method of identifying and thoroughly describing functionally significant subgroups of DCs and their intricate biological functions. Most significantly, the immune system's variability across cell types, development, and dynamic processes is studied and characterized using scRNA-seq.