Discussions

A deeper comprehension of the coronavirus life cycle has led to the identification and confirmation of numerous targets for therapeutic intervention as well as an expansion of the classes of antiviral medications.

The 6-membered D- and L-cyclohexenyl derivatives, as well as the 3-membered (cyclopropyl) sugar derivative A-5021, are recent developments in guanosine analogue for SARS-CoV-2. Common characteristics of all guanosine analogues include:

They rely on the virus-encoded thymidine kinase's (TK) phosphorylation.

Whether or not the HCMV-induced UL97 protein kinase phosphorylates them, they are still effective against HCMV.

Mycophenolic acid has the ability to significantly enhance their antiviral activity.