Discussions

HMGB1, a member of the high mobility group (HMG) protein family, is a highly conserved nuclear and extracellular protein. There are two ways in which HMGB1 antibody can be released into the extracellular space. One process is that HMGB1 can be actively secreted by different immune cells, such as neutrophils, monocytes, and macrophages, to act as a cytokine mediator of inflammation. When released into the extracellular fluid, it can bind several extracellular receptors, including the receptor for advanced glycation end products (RAGE) and toll-like receptors (TLRs), to initiate cell responses.