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C3 convertase belongs to a family of serine proteases and is necessary for innate immunity as a part of the complement system which eventuates in opsonization of particles, release of inflammatory peptides, C5 convertase formation and cell lysis. There are three pathways of complement activation, the classical pathway, lectin pathway, and alternative pathway. All pathways converge at the level of the C3 molecule, where downstream events can be amplified by a mechanism of positive feedback supported by complement convertases, the classical/lectin pathway C3 convertase (C4b2a) or the alternative pathway C3 convertase (C3bBb).

Pig Complement Factor H ELISA Kit is an ELISA kit for the determination of Pig Complement Factor H in the samples of Plasma and Serum. It is highly sensitive and available for the detection of Pig Complement Factor H as low as 14.063 ng/mL.

Complement Factor H is a protein with twenty short consensus repeat domains encoded by human CFH gene. It is a member of the regulators of complement activation family and is a complement control protein. It is a large (155 kilodaltons), soluble glycoprotein that circulates in human plasma (at typical concentrations of 200-300 micrograms per milliliter). Factor H is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Learn more about Sheep Anti-Human Complement Factor H Polyclonal Antibody.

Since the conventional cornerstones of cancer treatment (surgery, chemotherapy and radiation therapy) show more and more limitations for a variety of human malignancies, genetic engineering of the immune system has shown great promise in the treatment of cancer, especially the use of chimeric antigen receptor (CAR)-T cells. As the leading cell therapeutics biotech that provides CAR-T cell therapy related services, Creative Biolabs masters the most advanced technology and has a very rich extensive experience and thus, can offer the best CAR vector products and CAR design & construction services.

Immunotherapy has become a revolution in the area of cancer treatment. Compared to the traditional methods, such as invasive surgeries, radiation and chemotherapy, immunotherapy is more specific and less toxic to patients. CAR-engineered T cell therapy is the most promising approach, which has shown remarkable ability to eliminate various kinds of tumors, especially for B cell malignancies, with up to 95% response rates and durable complete remission.

Our MAPPS assay works efficiently with a turnaround time of 3-4 weeks. Firstly, antigen-presenting cells can figure out the protein and process/present peptide fragments existed in MHC molecules on the cell surface. Then, cells will be lyzed and HLA-peptide molecules will be recovered in an immune affinity step. Finally, peptides will be separated from the HLA molecules and be analyzed by LC-MS/MS. In this process, we are capable of identifying sequences after subjecting to rigorous analysis to identify true positive peptides with high confidence.

Creative Biolabs proudly offers clodronate liposomes. Clodronate liposomes are composed of clodronate molecules encapsulated in neutral liposomes, which are able to achieve the macrophage depletion after a single intravenous or intraperitoneal administration. Clodronate molecules encapsulated in small liposomes present superior activity, physical and chemical stability.