Discussions
Biomarker Assay
Biomarker results data have many uses and can be applied or utilized in different areas of science - from early research and biomarker discovery through drug development programs where they are used in early to late-stage clinical trials, to diagnostics and health management reviews. Creative Biolabs provides biomarker assay services to global neurobiological scientists to support your research.
CAR-T cell efficacy
Recent clinical trials have produced encouraging data for CAR-T cell therapy against various types of cancers, which inspires further development of CAR-T cell therapies. Preclinical in vivo therapeutic efficacy test of CAR-T cells in animal models provides valuable information for their later clinical application. With years of preclinical in vivo research and project management experience, Creative Biolabs is able to provide therapeutic efficacy test service for a proof-of-concept or CAR-T cell efficacy, by utilizing appropriate animal models, designing comprehensive research practices and handling high-quality in vivo studies.
CAR-T cell cytotoxicity assay
Creative Biolabs has developed various assay methods available for customers to measure the cytotoxicity of TCR-modified T cells. We always introduce vital dyes, protease biomarkers or by measuring ATP content to our clients. The formazan dyes are chromogenic products formed by the reduction of tetrazolium salts by dehydrogenases, which are released at cell death. We also monitor cytotoxicity by the use of the SRB and WST-1 assay which are high through methods. More than that, Creative Biolabs is willing to provide CAR-T cell cytotoxicity assay according to your requirement.
CAR-T cell design
Since the conventional cornerstones of cancer treatment (surgery, chemotherapy, and radiation therapy) manifest more and more limitations against multiple human malignancies, the novel immunotherapy is growing excitement with stutter steps, especially the CAR-T therapy. Hailed as "a living drug", CAR-T is an excellent example of the application of basic research to the clinic.
Macrophage Reprogramming
By applying our state-of-the-art Macrophage Therapeutics Development Platform as well as industry-leading expertise, Creative Biolabs provides overall solutions for macrophage reprogramming, focusing on innovative research. Our multidisciplinary scientists will work together closely to address the scientific and technical challenges in macrophage reprogramming.
Macrophage Polarization Assay
As a leading service provider in the field of antibody discovery and immunotherapy development, Creative Biolabs now presents one-stop development services for CAR-T therapy, which has become a more promising approach among cancer therapies. We offer macrophage polarization assay used to improve the antitumor immunity via promoting inflammation during the one-stop service for further downstream research.
macrophages markers
Rapid identification of macrophages and their polarization states provides valuable information for drug discovery, toxicological screening, and immunotherapy evaluation. Equipped with a team of skilled scientists with an innovative Platform, which is designed specifically to meet very challenging requirements in macrophage development, Creative Biolabs offers fast, reliable support for our clients' macrophage marker development projects.
Macrophage Isolation and Culture
Macrophages are able to initiate a particular type of inflammatory response via the release of a certain pattern of cytokines. They play a major role as immunoregulatory cells. Creative Biolabs has built a highly experienced team of scientists and quality staff that have a long history in macrophage isolation and culture. Human monocyte, human alveolar, murine peritoneal cavity, murine bone marrow, murine lung, and murine adipose tissues are available for macrophage isolation and culture. Our seasoned scientists are pleased to share our expertise and experience with our global clients and facilitate their meaningful macrophage project development.
Is it Safe to Drive with a Cracked Windshield?
Do I need enzyme stabilization & formulation as part of product development?
A: Enzyme formulation is one last and important step in commercializing an enzyme containing product. Nonetheless, the step has not yet received enough notice for its key role in effectively delivering the intended performance of the product. The main purpose of formulation is to preserve the enzyme in a ready-to-use form until consumed by the customer. Many companies spent a significant amount of resource and time on developing and testing the new enzyme product in details to deliver perfect biochemistry. However, final customers are only interested in the safety, stability, and aesthetics of the products on the shelf. Therefore, the product is only completed when it goes into the final package. At Creative Enzymes, we understand the importance of stable enzyme activity and will help you keep the enzymes stable during long-term storage. We also perform proper aging tests that predict the shelf life of an enzyme product using acceleration tests and kinetic models. In the end, we are happy to develop and optimize the product formulation for a specific enzyme.