Discussions
Deoxynucleotide Triphosphates
Deoxynucleotide triphosphates (dNTPs) are the nucleoside triphosphates containing deoxyribose. dNTPs are the essential building blocks of nucleic acid molecules, and as such are necessary components of PCR mixes as no new amplified DNA could be generated without them. The four individual deoxynucleotides which make up a DNA sequence including deoxyadenosine triphosphate (dATP), deoxythymidine triphosphate (dTTP), deoxycytosine triphosphate (dCTP) and deoxyguanosine triphosphate (dGTP). In addition, the quality of dNTPs also critical for the success of many key procedures such as PCR, cDNA synthesis, qPCR, sequencing, cloning and DNA labeling.
adcp assay
Our ADCC assays can help you understand whether your biologics binds to the target antigen, activates immune cells through their Fc receptors, initiates cell death, or alternatively determines if Fc-silencing methods are effective. Our ADCC assay portfolio also includes surrogate ADCC assays using engineered cell lines that stably express the FcγRIIIa receptor to eliminate donor-specific variability and provide viable solution for validation of these complex assays.
mea electrophysiology
Microelectrode array (MEA) is one of the most sophisticated and efficacious technologies for measuring changes in spontaneously-active cells, such as cardiomyocytes and neurons. With our decades expertise in the production of MEA test, we are experts in the development and application of MEA-based drug screening approaches.
Waymouth MB 752/1 Medium, Powder
Waymouth MB 752/1 Medium was originally developed for the cultivation of L929 cells in a serum-free environment. It has been widely used in whole organ culture, establishment of carcinoma cell lines from pleural effusions, and the growth of potentially tumorigenic cells.
Microfluidic Health Monitoring
Microfluidic health monitoring devices provide revolutionary tools for biological diagnostics and industrial applications. Miniaturized microfluidic sensors integrate key steps such as sample collection, separation, and detection into a single chip and realize automatic and multi-functional analysis. The microfluidic chip is easy to operate, easy to carry, and convenient for on-site deployment, providing a new option for tedious and time-consuming laboratory testing. Microfluidic technology can be further combined with electrochemical, optical, mass spectrometry, and other technologies to greatly expand its function and usability. Microfluidic systems have a wide range of applications in public health monitoring, including food safety management, environmental monitoring, veterinary diagnostics, organic wastewater treatment, and forensic science.
Exosome Applications
Exosomes have specialized functions and play a key role in different physiological processes and pathological conditions. Consequently, exosomes have attracted increasing attention in their clinical applications for prognosis, diagnosis, drug delivery, and vaccine development. Here, we give an introduction to the different exosome applications.
Asialoglycoprotein Receptor
Immunoglobulin A (IgA) is the most abundantly produced antibody isotype in mammals. The primary function of IgA is to maintain homeostasis on mucosal surfaces and play a role in immune protection. IgA functions mainly through interaction with multiple receptors, including the asialoglycoprotein receptor (ASGPR). ASGPR is a type C carbohydrate-binding lectin that mediates the clearance of various defective plasma glycoprotein molecules from the body. These receptors also identify and bind to pathogen membrane glycoproteins to efficiently clear them from circulation by receptor-mediated endocytosis and play a pivotal role in preventing hepatocyte infections, inflammation, and cancer.
Midbody Ring
At the end of cytokinesis, the dividing cells are connected by an intercellular bridge, containing the midbody along with a single, densely ubiquitylated circular structure called the midbody ring (MR). MRs are large (about 1.5 m), ring-like macromolecular assemblies that contain several proteins, including centriolin2, MKLP1 (ref. 7), the de-ubiquitylation enzyme USP8 (also known as UBPY)8, and the multifunctional anti-apoptotic ubiquitin ligase BRUCE3, 9, which has a relative molecular mass of 528,000 (Mr 528K).
In Vitro Diagnostics
In vitro diagnostics (IVD) are tests used to detect and diagnose disease, infections, or other medical conditions, including the state of health, in order to cure, mitigate, treat, or prevent disease or its sequelae. They’re intended for use in the collection, preparation, and examination of specimens taken from the human body.